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Edward A Sausville Selected Research

EC145

12/2013PRECEDENT: a randomized phase II trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer.
11/2012Phase I study of folate conjugate EC145 (Vintafolide) in patients with refractory solid tumors.
2/2011Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications.
12/2009Clinical pharmacokinetics and exposure-toxicity relationship of a folate-Vinca alkaloid conjugate EC145 in cancer patients.

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Edward A Sausville Research Topics

Disease

73Neoplasms (Cancer)
01/2020 - 01/2002
21Leukemia
01/2019 - 12/2002
12Breast Neoplasms (Breast Cancer)
04/2016 - 01/2002
11Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2020 - 12/2003
9Carcinoma (Carcinomatosis)
04/2016 - 02/2002
5Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2020 - 10/2003
5Ovarian Neoplasms (Ovarian Cancer)
12/2013 - 09/2003
5BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
06/2013 - 01/2002
4Glioma (Gliomas)
05/2017 - 08/2002
4Prostatic Neoplasms (Prostate Cancer)
01/2016 - 12/2006
4Squamous Cell Carcinoma of Head and Neck
12/2005 - 11/2002
4Melanoma (Melanoma, Malignant)
08/2005 - 04/2004
3Diarrhea
11/2014 - 02/2003
3Lymphoma (Lymphomas)
01/2010 - 06/2005
3Hypoxia (Hypoxemia)
09/2005 - 08/2002
3Neoplasm Metastasis (Metastasis)
08/2005 - 10/2003
2Philadelphia Chromosome
01/2019 - 07/2011
2Hyperglycemia
04/2016 - 01/2010
2Hematologic Neoplasms (Hematological Malignancy)
05/2014 - 02/2002
2Ovarian Epithelial Carcinoma
12/2013 - 11/2012
2Constipation
02/2011 - 12/2009
2Myeloid Leukemia (Leukemia, Myelocytic)
03/2009 - 04/2007
2Kaposi Sarcoma (Kaposi's Sarcoma)
08/2006 - 04/2004
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
11/2005 - 03/2002
2Adenocarcinoma
08/2005 - 08/2004
1Thrombosis (Thrombus)
01/2020
1Hypersensitivity (Allergy)
01/2020
1Pancreatitis
01/2020
1Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Leukemia, Pre B Cell)
01/2019

Drug/Important Bio-Agent (IBA)

27Pharmaceutical PreparationsIBA
11/2014 - 01/2002
15Proteins (Proteins, Gene)FDA Link
04/2015 - 02/2002
97-hydroxystaurosporine (UCN 01)IBA
10/2013 - 11/2002
8NSC 680410IBA
12/2006 - 01/2002
7Antineoplastic Agents (Antineoplastics)IBA
01/2017 - 01/2002
7Cyclin-Dependent Kinases (cdk Proteins)IBA
10/2013 - 01/2002
7entinostat (MS 275)IBA
04/2007 - 02/2002
6tanespimycin (17AAG)IBA
07/2010 - 09/2003
6alvocidib (flavopiridol)IBA
01/2005 - 05/2002
5Tyrosine Kinase InhibitorsIBA
01/2019 - 12/2002
5perifosineIBA
11/2014 - 03/2002
5Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2007 - 12/2002
5Messenger RNA (mRNA)IBA
07/2006 - 09/2003
52- (4- amino- 3- methylphenyl)- 5- fluorobenzothiazoleIBA
07/2006 - 02/2002
5Phosphotransferases (Kinase)IBA
11/2005 - 01/2002
4DNA (Deoxyribonucleic Acid)IBA
05/2017 - 09/2004
4Folic Acid (Vitamin M)FDA LinkGeneric
12/2013 - 12/2009
4EC145IBA
12/2013 - 12/2009
4Histone Deacetylase InhibitorsIBA
04/2007 - 01/2005
4tyrphostin AG957IBA
12/2006 - 12/2002
4Cytochrome P-450 CYP1A1 (CYP1A1)IBA
07/2006 - 12/2003
3Asparaginase (Elspar)FDA Link
01/2020 - 05/2014
3NaphthoquinonesIBA
01/2017 - 01/2016
3Biomarkers (Surrogate Marker)IBA
05/2013 - 11/2002
3AlkaloidsIBA
11/2012 - 12/2009
3Imatinib Mesylate (Gleevec)FDA Link
07/2011 - 01/2002
3Cytarabine (Cytosar-U)FDA LinkGeneric
03/2009 - 12/2002
3benzothiazoleIBA
07/2006 - 01/2002
317- (dimethylaminoethylamino)- 17- demethoxygeldanamycinIBA
12/2005 - 08/2005
3Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA
02/2005 - 01/2002
3Complementary DNA (cDNA)IBA
02/2004 - 03/2003
3Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
10/2003 - 02/2002
2blinatumomabIBA
01/2019 - 01/2019
2Glutamine (L-Glutamine)FDA Link
01/2018 - 05/2014
2ErbB Receptors (EGF Receptor)IBA
04/2016 - 09/2007
2Reactive Oxygen Species (Oxygen Radicals)IBA
01/2016 - 12/2003
2Proteasome InhibitorsIBA
10/2013 - 12/2005
2Proteasome Endopeptidase Complex (Proteasome)IBA
10/2013 - 12/2005
2LigandsIBA
11/2012 - 01/2006
2HydrazinesIBA
11/2012 - 12/2009
2Insulin (Novolin)FDA Link
01/2010 - 11/2004
2Integrin beta3 (GPIIIa)IBA
11/2009 - 06/2009
2arginyl-glycyl-aspartic acidIBA
11/2009 - 06/2009
2Heat-Shock Proteins (Heat-Shock Protein)IBA
11/2009 - 09/2003
2geldanamycinIBA
11/2009 - 06/2009
2N-(2-hydroxypropyl)methacrylamideIBA
11/2009 - 06/2009
2hydroxypropyl methacrylateIBA
11/2009 - 06/2009
2Drug CombinationsIBA
03/2009 - 10/2003
2Monoclonal AntibodiesIBA
09/2007 - 11/2003
2G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
08/2006 - 04/2004
2Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
07/2006 - 02/2002
2Peptides (Polypeptides)IBA
01/2006 - 10/2004
2NF-kappa B (NF-kB)IBA
12/2005 - 02/2005
2Biological ProductsIBA
11/2005 - 07/2004
2Cyclin D1IBA
08/2005 - 05/2002
2NSC 674495IBA
12/2004 - 01/2002
21,1'- ((propane- 1,3- diyl)dioxy)bis(7- methoxy- 2- methylidene- 1,2,3,10,11,11a- hexahydro- 5H- pyrrolo(2,1- c)(1,4)benzodiazepin- 5,11- dione)IBA
09/2004 - 09/2004
2Cisplatin (Platino)FDA LinkGeneric
09/2004 - 07/2004
2ElementsIBA
06/2004 - 08/2002
2Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
02/2004 - 09/2003
2CaspasesIBA
02/2004 - 09/2003
2AntibodiesIBA
11/2003 - 06/2003
2Protein Kinase CIBA
09/2003 - 11/2002
1pegaspargase (Oncaspar)FDA Link
01/2020
1ponatinibIBA
01/2019

Therapy/Procedure

20Therapeutics
01/2019 - 08/2002
6Drug Therapy (Chemotherapy)
01/2019 - 12/2002
3Aftercare (After-Treatment)
02/2004 - 02/2002
2Induction Chemotherapy
01/2020 - 07/2015
2Radiotherapy
06/2013 - 12/2005
2Combination Drug Therapy (Combination Chemotherapy)
03/2009 - 11/2005